Journal: Materials Today Bio
Article Title: Self-assembled nanoparticles from Xiexin Decoction attenuate ulcerative colitis by targeting VDAC1-Mediated NLRP3 inflammasome activation
doi: 10.1016/j.mtbio.2026.103078
Figure Lengend Snippet: Gastrointestinal stability and biodistribution of RBNPs. (A – C) Hydrodynamic diameter (A), PDI (B), and zeta potential (C) of RBNPs incubated in PBS, SGF, or SIF. (D) In vitro cumulative release profiles of BBR from RBNPs in SGF and SIF over 48 h. (E – F) Representative in vivo fluorescence images (E) and quantification of radiant efficiency (F) in mice following oral administration of Cy5.5@RBNPs or free Cy5.5. (G) Ex vivo fluorescence images of major organs (H, heart; Lu, lung; Li, liver; S, spleen; K, kidney) and colons excised at indicated time points. (H) Quantification of radiant efficiency in major organs and colons. Data are presented as mean ± SD ( n = 3). Statistical significance was assessed by one-way ANOVA with Tukey's post hoc test, ∗∗∗∗ p < 0.0001; ns, not significant.
Article Snippet: MedChemExpress supplied the Cy5.5 dye.
Techniques: Zeta Potential Analyzer, Incubation, In Vitro, In Vivo, Fluorescence, Ex Vivo